{"product_id":"platelet-derived-growth-factor-bb-pdgf-bb-gr-005","title":"Platelet-derived growth factor-BB (PDGF-BB) (GR006)","description":"\u003ctable style=\"border-collapse: collapse;\" width=\"100%\" data-mce-style=\"border-collapse: collapse;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: 1px solid black; width: 46.6089%; text-align: center;\" data-mce-style=\"border: 1px solid black; width: 46.6089%; text-align: center;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0632\/0367\/2281\/files\/PDGF-BB_GR006__PI.pdf?v=1690246475\" target=\"_blank\"\u003e\u003cstrong\u003e제품 설명서 (PDF 파일 다운로드)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd style=\"border: 1px solid black; width: 53.3911%; text-align: center;\" colspan=\"2\" data-mce-style=\"border: 1px solid black; width: 53.3911%; text-align: center;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0632\/0367\/2281\/files\/PDGF-BB_GR006_GHS_SDS_welgene.pdf?v=1698107183\" target=\"_blank\" rel=\"noopener noreferrer\"\u003e\u003cstrong\u003eMSDS (PDF 파일 다운로드)\u003c\/strong\u003e\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStable-Basic Fibroblast Growth factor\u003cbr\u003e\u003c\/strong\u003erecombinant, Human\u003cbr\u003eexpressed in E.Coli\u003c\/p\u003e\n\u003cp\u003eCatalog Number\u003cbr\u003e\u003cstrong\u003eGR 006-010 (10ug)\u003cbr\u003e\u003c\/strong\u003e\u003cstrong\u003eGR 006-050 (50ug)\u003cbr\u003e\u003c\/strong\u003e\u003cstrong\u003eGR 006-200 (200ug)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eStorage Temperature -5 ~ -20°C\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrecautions\u003cbr\u003e\u003c\/strong\u003eFor \u003cem\u003eIn Vitro \u003c\/em\u003eUse Only\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Description\u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePlatelet-derived growth factor (PDGF) is a dimeric molecule that exists as a homodimer or as a heterodimer of the polypeptide chains. And these polypeptide chains are linked by disulfide bonds. PDGF is expressed in five forms: PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD. Platelet-Derived Growth Factor BB (PDGF-BB) is a member of the platelet-derived growth factor family and plays a crucial role in regulating cell growth, proliferation, and differentiation in various tissues.\u003c\/p\u003e\n\u003cp\u003ePDGF-BB is primarily produced by platelets, endothelial cells, and smooth muscle cells and plays roles by binding to the PDGF receptor (PDGFR) on the surface of cells, leading to the activation of intracellular signaling pathways that regulate various cellular processes.\u003c\/p\u003e\n\u003cp\u003eThe main function of PDGF-BB is to stimulate the growth and division of mesenchymal cells, including fibroblasts and smooth muscle cells. It is involved in various physiological and pathological processes, such as wound healing, tissue repair, and cancer. In wound healing and tissue repair, PDGF-BB stimulates the growth and migration of fibroblasts, which are essential for the formation of granulation tissue and extracellular matrix. PDGF-BB has also been used in medical treatments for various conditions, such as chronic wounds, ulcers, and bone fractures. It has been shown to have potential therapeutic applications in the promotion of tissue regeneration and healing. In cancer, PDGF-BB has been found to be overexpressed in various types of tumors, where it promotes cell proliferation, angiogenesis, and metastasis.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Information\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAlternative Names :\u003cbr\u003e\u003c\/strong\u003e\u003cspan style=\"font-size: 0.875rem;\"\u003ePlatelet-Derived Growth Factor-BB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF)\u003cbr\u003e\u003c\/span\u003e\u003cstrong\u003eSpecies :\u003c\/strong\u003e Human\u003cbr\u003e\u003cstrong\u003eSource :\u003c\/strong\u003e Pichia\u003cbr\u003e\u003cstrong\u003ePredicted Molecular Mass :\u003c\/strong\u003e 24.6kDa\u003cbr\u003e\u003cstrong\u003eAmino Acid Sequence :\u003cbr\u003e\u003c\/strong\u003eSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVT\u003cbr\u003e\u003cstrong\u003eFormulation : \u003cbr\u003e\u003c\/strong\u003eLyophilized from a sterile-filtered aqueous solution containing 20mM Sodium Phosphate, pH 7.0\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Specifications\u003c\/strong\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBiological activity :\u003cbr\u003e\u003c\/strong\u003eThe EC\u003csub\u003e50\u003c\/sub\u003e ≤ 5.0 ng\/mL as determined by a cell proliferation assay using BALB\/ 3T3 cells.\u003cbr\u003e\u003cstrong\u003ePurity : \u003cbr\u003e\u003c\/strong\u003e≥ 95% purity by SDS-PAGE\u003cbr\u003e\u003cstrong\u003eEndotoxin : \u003cbr\u003e\u003c\/strong\u003e≤ 0.5 EU\/mg protein by LAL(Limulus amebocyte lysate) analysis method.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePreparation and Storage\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage :\u003cbr\u003e\u003c\/strong\u003eStore at -5 °C to -20 °C.\u003cbr\u003e\u003cstrong\u003eStability : \u003cbr\u003e\u003c\/strong\u003eStable as supplied for 12 months from date of receipt.\u003cbr\u003e\u003cstrong\u003ePreparation : \u003cbr\u003e\u003c\/strong\u003eCentrifuge vial before opening. Reconstitute the product in sterile water to at least 0.1 mg\/mL by pipetting the solution down the sides of the vial. Do not vortex\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDATA\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e(A) The biological activity of Human Recombinant PDGF-BB was tested by its ability to promote the proliferation of BALB\/c 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the under example is 4.44 ng\/mL.\u003cbr\u003e (B) Human Recombinant PDGF-BB was resolved with SDS-PAGE under and visualized by Coomassie Blue staining. Human Recombinant PDGF-BB  has a predicted molecular mass of 24.6 kDa.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cimg alt=\"\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0632\/0367\/2281\/files\/Platelet-derivedgrowthfactor-BB_PDGF-BB_2048x2048.jpg?v=1689743975\"\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Welgene","offers":[{"title":"10ug - 본사 문의","offer_id":43992920195289,"sku":null,"price":291000.0,"currency_code":"KRW","in_stock":true},{"title":"50ug - 본사 문의","offer_id":43992920228057,"sku":null,"price":726000.0,"currency_code":"KRW","in_stock":true},{"title":"200ug - 본사 문의","offer_id":43992920260825,"sku":null,"price":1669000.0,"currency_code":"KRW","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0632\/0367\/2281\/files\/GR006_new.jpg?v=1716276173","url":"https:\/\/en.welgene.com\/ko\/products\/platelet-derived-growth-factor-bb-pdgf-bb-gr-005","provider":"Welgene","version":"1.0","type":"link"}